| abstract |
A therapeutic composition for oral administration comprises a gelatin capsule containing spheroids of active medicinal substance film coated with an undercoat and an overcoat. The capsule may contain three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance, a second group of spheroids is coated with a pH sensitive coat to provide a second dose and a third group of spheroids is coated with a pH independent coat to provide a third dose. A powder blend of active medicinal substance may be substituted for the first group of uncoated spheroids. |