| abstract |
The present invention relates to proteins derived from the p53 tumor suppressor gene product, having improved functions for therapeutic use. It advantageously relates to proteins having improved tumor suppressor and programmed cell death inducer functions, more particularly in proliferation pathological contexts in which the wild-type p53 protein is inactivated. It also relates to the nucleic acids coding for these molecules, the vectors containing them and their therapeutic uses, in particular in gene therapy. |