abstract |
The subject of the invention is a method for attaching a marker group to a peptide, consisting in acylating the alpha amino function of the peptide with a labeling reagent comprising an activated carboxylic function, at a pH of between approximately 7.5 and 5. , 5. The carboxylic function of the labeling reagent is advantageously activated in the form of an ester of N-hydroxysuccinimide; the labeling reagent can in particular be the Bolton-Hunter reagent. |