| abstract |
The present invention provides a method for screeningna compound or its salt that alters the binding propertynbetween MCH or its salt and SLC-1 or its salt, characterizednby using MCH or its derivative or a salt thereof and SLC-1nor its salt; and the like. n The method for screening a compound or its salt thatnalters the binding property between MCH or its salt and SLC-1nor its salt, characterized by using MCH or its derivativenor a salt thereof and SLC-1 or its salt is useful for screeningnan SLC-1 agonist which can be used not only as an appetiten(eating) promoting agent but also as anprophylactic/therapeutic agent for weak pains, atonicnbleeding, before and after expulsion, subinvolution ofnuterus, cesarean section, induced abortion, galactostasis,netc., and an SLC-1 antagonist which can be used not onlynas an antiobestic agents (drug), an appetite (eating)nmodulator, etc. but also as a prophylactic/therapeutic agentnfor hyperstimulation, ankylosing uterine contractions,nfetal distress, uterine rupture, cervical laceration,npreterm delivery, Prader-Willi syndrome, etc. |