| abstract |
The invention provides solid pharmaceutical compositions, preferably soft gelatin capsules, comprising a light-sensitive active component optionally barely soluble in water, preferably nifedipine [4- (2'-nitrophenyl) -2, 6-dimethyl-3,5-dimethoxycarbonyl 1,4-dihydropyridine], with conventional carriers and / or auxiliary agents, these compositions comprising a vegetable dye. In addition, the invention relates to the preparation of these compositions. The incorporation of a vegetable dye in the filler of the capsule and possibly in the wall of the capsule provides reliable protection against light during the manufacturing and filling operations and improves the solubility of nifedipine in certain carriers. |