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filingDate 1988-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7358c791babc72516b72aa328f071015
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publicationDate 1989-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber FR-2617403-A1
titleOfInvention PROCESS FOR THE PREPARATION OF NUCLEIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION OF A MEDICAL COMPOSITION CONTAINING THEM
abstract A process for the preparation of calibrated double stranded nucleic acid polymers in which single stranded nucleic acid polymers are calibrated and then annealed. By this method, double-stranded nucleic acid derivatives having RNA as a related body can be obtained, the molecular size distribution of which is in the range of the sedimentation constant value from 4S to 13S, as well as those in which molecules for the maximum distribution in the total distribution of molecular sizes of the derivatives have base numbers in the range of 50 to 10,000. The process is industrially advantageous since the reaction rate is high and the product yield is high . The products can be used as an active ingredient as an antitumor composition or an antiviral composition since these have strong physiological activities and are not very toxic.
priorityDate 1987-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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