| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-785 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785 |
| filingDate |
1980-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23679847f9d3262124f17e336a886e5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2622549ecb798647c5d3dffd40225d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90e002af93d40263cccbc5ad2bd19354 |
| publicationDate |
1981-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0025766-A2 |
| titleOfInvention |
Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates |
| abstract |
A complex of polyriboinosinic-polyribocytidylic acid (poly I:C) with poly-L-lysine hydrobromide ([Iysine.HBr] n ) having a defined molecular weight is prepared which is about 5-15 times as resistant to hydrolysis by pancreatic ribonuclease as the parent poly I:C. A pharmaceutical solution, containing a relatively high concentration of the complex, prepared as described, induces significant antiviral levels of serum interferon in monkeys under conditions in which poly I:C itself induces little or no interferon. An important feature of this invention is that the product is a soluble material requiring no special solubilizing agent, thereby facilitating the preparation of solutions having the desired concentration. The product will hereinafter be designated as poly I:C/poly-L-lysine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6545138-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5624912-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8303965-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8303966-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5977083-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2207138-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2207138-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2207432-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2617403-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2617486-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7838017-B2 |
| priorityDate |
1979-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |