abstract |
CHIRAL DERIVATIVES OF HYDROXYPHENYLGLYCINE AND THEIR USE IN THE SYNTHESIS OF ACTIVE PHARMACEUTICAL PRINCIPLES. THE CHIRAL DERIVATIVES OF HYDROXYPHENYL GLYCIN, WITH CONFIGURATION D, HAVE THE GENERAL FORMULA (I), WHERE R IS H, HYDROXY, CHLORIDE, -NH2, -NHW, WHERE W IS AN ALKYL GROUP C1-C4 OR ARYL, -OR ", WHERE R "IS A C1-C4 ALKYL GROUP, AND Z IS H, -CONH2 AND -C (CH3) = CHCOOY, WHERE Y IS METHYL OR ETHYL. ONE OF THESE COMPOUNDS, D - (-) - 2- (2 '' - HYDROXYPHENIL) GLYCINE CAN BE OBTAINED BY THE ENZYMATIC ROUTE FROM THE CORRESPONDING HYDANTOIN WHILE THE OTHERS CAN BE OBTAINED BY CHEMICAL OR ENZYMATIC ROUTES. THE COMPOUNDS OF FORMULA (I) ARE USEFUL FOR THE PRODUCTION OF DRUGS, IN PARTICULAR, FOR SEMI-SYNTHETIC PENICILLINS, CEPHALOSPORINS, NON-STEROID ANTI-INFLAMMATORY AND MUCOLIC. |