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publicationDate 2021-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3925971-A1
titleOfInvention Method for identifying compounds influencing virus receptor binding
abstract The present invention relates to a method for identifying a compound enhancing, not affecting or inhibiting the binding of a virus to a receptor protein of said virus comprising the steps of na) incubating a first solid support comprising said receptor protein or a functional fragment thereof immobilized thereon with said virus or a fragment thereof; nb) incubating a second solid support comprising said receptor protein or functional fragment thereof immobilized thereon with said virus or fragment thereof in the presence of said compound; nc) determining the virus-receptor binding levels resulting from step a) and step b); nd) comparing the binding levels determined in step c), and ne) identifying said compound as a compound enhancing virus-receptor binding if the binding level resulting from step b) is higher than the binding level resulting from step a), nf) identifying said compound as a compound not affecting virus-receptor binding if the binding level resulting from step b) is substantially identical to the binding level resulting from step a), and ng) identifying said compound as a compound inhibiting virus-receptor binding if the binding level resulting from step b) is lower than the binding level resulting from step a) .
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