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filingDate 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6408c7c92299add486c63641f6644dcb
publicationDate 2020-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3744860-A1
titleOfInvention Primer and probe set for diagnosis, detection, or screening of colorectal cancer
abstract The present invention relates to the biomedical field, and relates to a primer and probe set for diagnosis, detection or screening of colorectal cancer, including amplification primers, a blocker primer, and a probe of SEPT9, and amplification primers, a blocker primer, and a probe of SDC2. A forward primer of SEPT9 is selected from any one of SEQ ID NOs: 1-25, a reverse primer of SEPT9 is selected from any one of SEQ ID NOs: 26-51, the blocker primer of SEPT9 is selected from any one of SEQ ID NOs: 52-67, and the probe of SEPT9 is selected from any one of SEQ ID NOs: 68-90. A forward primer of SDC2 is selected from any one of SEQ ID NOs: 91-117, a reverse primer of SDC2 is selected from any one of SEQ ID NOs: 118-143, the blocker primer of SDC2 is selected from any one of SEQ ID NOs: 144-156, and the probe of SDC2 is selected from any one of SEQ ID NOs: 157-174. Compared with the prior art, the present invention has the beneficial effect of simultaneously detecting methylation levels of SEPT9 and SDC2 with high sensitivity and specificity, for use in screening/detection/diagnosis of early-stage colorectal cancer.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022139581-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-2027228-B1
priorityDate 2018-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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