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filingDate 2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3437662-A1
titleOfInvention Il-12 immunoconjugate
abstract Conjugate comprising interleukin-12 (IL-12) and a single chain targeting portion comprising two antigen binding sites. The targeting portion may comprise an antibody fragment such as a single chain diabody. The conjugate may be a single chain fusion protein. Use of single chain bivalent IL-12 immunocytokine for targeting the extra-cellular matrix (ECM) of tissues, particularly tumour neovasculature antigens, for example fibronectin. Use for treating cancer or pathological angiogenesis in a patient.
priorityDate 2011-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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