http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3318247-A1

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filingDate 2012-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27f26b49c0e26d872641458a3a1b27b8
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publicationDate 2018-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3318247-A1
titleOfInvention Taste masked pharmaceutical composition
abstract This application relates to taste masked multi-layered particles comprising a pharmaceutically active ingredient, comprising: (a) an inert core, (b) one or more coating layer(s) comprising the pharmaceutically active ingredient and a binder, (c) an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound, comprising a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP and (d) an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound comprising (i) a poly(meth)acrylate or (ii) a mixture comprising 60-90% (w/w) EC and 10-40% (w/w) HPMC, wherein the pharmaceutically active ingredient is water-soluble and comprises either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions comprising them.
priorityDate 2011-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415841566
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP13190
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419474364
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5312542
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID451113904
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ98TA8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP09682
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID422126995
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226406200
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01308
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226406201
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226928662
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11177
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68243
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68245
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID45031
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6581
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9TQY7
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID29527
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID453
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395133
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP09567
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226401602
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01321
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID17869
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID228568843
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01324
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID396451
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01328
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6XGL2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01330
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3083511
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID15324
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01316
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID448380735
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01317
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID104938
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419522566
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID450985629
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01319
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID53468015
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419512635
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID134664
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9NDE7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01320
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID16186314
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID227102913
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6YK33
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01314
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395910
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID239673000
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01315
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456922693
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395911
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426080742
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID24882991
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID239673001
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID4072
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID443460
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID246226
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID412667134
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6781
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID246227
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID87569328
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100301982
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458394795
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID78738
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C235
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68273
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID139200
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C236
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68274
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68275
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID442942
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68260
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID452465968
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01339
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01340
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID16132283
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01342
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226554988
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID25253
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226554989
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226406378
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01331
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6917

Total number of triples: 384.