| abstract |
The invention relates to a substance for restoring normal coexpression and interaction between LOX and NRAGE proteins.n n n The invention relates in particular to the use of an effective amount of at least one substance modulating the expression and / or the activity of LOX having the sequence ID No. 1 and / or modulating the expression and / or the NRAGE activity having the sequence ID No. 2 for the manufacture of a composition intended to modulate the interaction between the LOX and NRAGE proteins to regulate the balance between the cell proliferation, differentiation and apoptosis phenomena, in particularly in cases where the equilibrium between these phenomena is disturbed, especially in cases where the interaction between LOX and NRAGE is absent or impaired.n n n The invention notably makes it possible to prevent or treat skin aging, lichen planus, graft-versus-host disease (GVHD), eczema, psoriasis, and cancer, particularly epithelial cancer. in particular cutaneous epithelial cancer, of the basal cell type, or of the squamous cell type |