| abstract |
Condensed tricyclic pyrazole compounds having affinity for the CB1 and/or CB2 cannabinoidergic receptors, with activity both on the peripheral and central nervous system, of formula (I) :n nwherein: nA represents a group selected from -(CH 2 ) t -, -(CH 2 ) r -O-(CH 2 ) s - and -(CH 2 ) r -S(O) p -(CH 2 ) s - nB is an heteroaryl, nR is a group selected from heteroaryl, heteroarylalkyl, aryl, arylalkyl, arylalkenyl or bivalent aliphatic chain, nR' is a group selected from the following: nR' 1 : a substituent bearing a keto group of formula -C(O)-(Z') v -Z" nR' 2 : a substituent having an hydroxylic function of formula -CH(OH)-(Z') v -Z", nR' 3 : an amide substituent of formula -C(O)-NH-(Z') v -T'. |