| abstract |
The present invention relates to compounds of general formula (I):n nwherein: n- R 1 , R 2 and R 3 mean, independently from the others, an hydrogen atom or an optionally substituted lower alkyl, a (C 1 -C 7 )acyl group or a benzyl, n- R 4 is an optionally substituted and/or interrupted hydrocarbon linker, n- X and Y are selected independently from each other from the group consisting of -NH-, -NR'-, -CO-, -NH(CO)-, -NH(CO)NH-, -NR'(CO)-, -O(CO)NH-, -O(CO)NR'-, -(CO)NH-, -(CO)NR'-, -NH(CO)(R")NH(CO)-, -(CO)NH(R"(CO)NH-, -O-, -(CO)O-, -NH(CO)O-, -SC(O)NH-, -NHSO 2 -, -NR'SO 2 - and -O(CO)- and preferably are different one from the other, with R' being an optionally substituted lower alkyl group, and R" being a (C 1 -C 3 ) alkylene, n- Z moiety represents an anti-neoplasic agent, n- n means 0 or 1, n- and the pharmaceutically acceptable salts thereof. nIt relates also to the use of such compounds as anti cancer agents. |