http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108434457-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3348 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-334 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108434457-B |
| titleOfInvention | Adriamycin polyethylene glycol epothilone B conjugate and preparation method thereof |
| abstract | The invention relates to an adriamycin pegylated epothilone B and a preparation method thereof, and the method mainly comprises the following steps: 1) reacting adriamycin with hydrazide polyethylene glycol carboxyl under the action of phosphoric acid to obtain an adriamycin polyethylene glycol carboxyl intermediate, wherein the molar ratio of adriamycin to phosphoric acid is 1: 0.01-0.02; 2) under the action of a second coupling agent and a catalyst, the epothilone B reacts with the adriamycin polyethylene glycol carboxyl intermediate to obtain the adriamycin pegylated epothilone B conjugate. |
| priorityDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.