| abstract |
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds ofnFormula In nand pyrimidine-thioalkyl and alkylethers of Formula IA, namely the compounds ofnFormula I where nR 4 is selected from the group consisting of -H or -NR 15 R 16 where R 15 is -H and R 16 nis -H, C 1 -C 6 alkyl, -NH 2 or R 15 and R 16 taken together with the -N form 1-pyrrolidino, 1-morpholinonor 1-piperidino; and nR 6 is selected from the group consisting of -H, or halo (preferably -CI);nwith the overall provisio that R 4 and R 6 are not both -H; nThe compounds of Formula IA are useful in the treatment of individuals who are HIVnpositive being inhibitors of viral reverse transcriptase. |