| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07b71571160c289fbf5fc680dfea513f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-721 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 |
| filingDate |
2003-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3936ceaafdaf01857ee5a91875acc6a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7267ad74174ba2ab8af6edce6837f42f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d9a54ec61d36dd729232eaf36b2e501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6de99735ca2c6875c6410fbd5fe889d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba5fe03c04b05e181c411c4e0b6baf49 |
| publicationDate |
2004-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1375517-A1 |
| titleOfInvention |
Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same |
| abstract |
A solved three-dimensional crystal structure of a glucocorticordnreceptor (GR) α ligand binding domain polypeptide is disclosed, in the form ofna crystalline glucocorticord receptor α ligand binding domain polypeptide inncomplex with the ligand fluticasone propionate (FP) and a peptide derivednfrom the co-activator TIF2. The GR/FP/TIF2 structure includes an expandednbinding pocket not seen in other GR structures. Methods of designing steroidnand non-steroid modulators of the biological activity of GR and other nuclearnreceptors (NRs) are also disclosed. In another aspect of the present inventionnhomology models of androgen receptor (AR), progesterone receptor (PR) andnmineralcorticoid receptor (MR) are disclosed, as well as methods of formingnhomology models for other NRs. Methods of forming a soluble GR/FP/TIF2ncomplex are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7442554-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1575502-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7442794-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-009958-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005035518-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1575502-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007008897-A |
| priorityDate |
2002-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |