| abstract |
The present invention provides medicinal compositions characterized byncontaining as the active ingredient either a compound represented by a general formulan(1) or a pharmaceutically acceptable composite thereof,n n [wherein X represents oxygen or sulfur; R 1 represents hydrogen, C 1-4 alkyl,netc.; R 2 represents, e.g., phenyl optionally substituted by A 1 ; R 3 represents, e.g.,nhydrogen, C 1-4 alkyl optionally substituted by A 2 , or a group represented by either onenof the following formulae;n n R represents oxygen, sulfur, or a group represented by a formula (N-G)], innparticular, inhibitor of phospholipase A(2) activity; use of the composition; andncompound represented by a general formula (1-1);n nwherein X, R 1 , R 2 , R 3 and G 1 are the same as defined in the description. |