| abstract |
The present invention provides a novel pharmaceutical compositionncontaining an anti-Fas antibody which is useful as an agent for prophylaxis and/orntreatment of an autoimmune disease or rheumatoid arthritis. n More particularly, the present invention provides a pharmaceuticalncomposition containing an anti-human Fas antibody having apoptosis inducingnactivity and a compound having a folate antagonist activity or a dihydrofolatenreductase inhibiting activity, as active ingredients. n According to the present invention, the amount of the anti-Fas antibody to benused can be reduced in an agent for prophylaxis and/or treatment of an autoimmunendisease or rheumatoid arthritis, and thereby, the possibility that the patient becomesntolerant to anti-Fas antibody as a result of the production of antibodies against thenanti-Fas antibody in the patient's body or the like can be decreased, and thus there cannbe provided a pharmaceutical composition of the present invention useful as annexcellent agent for prophylaxis and/or treatment which can be used for a long time. |