| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45c0430dd45ca6c64640c228acd8a48c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10332 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-761 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate |
2000-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cf50ba173616aad518ad1b1bdb3bd29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b05daeeb49af87bea5d4509eee669224
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0f897c9cfe5b29e0ffa2ee3cdaace8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0aceecc5213b7edc87f59cdc0cf596c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0d6b15781519ccdfccfd0016cedf764
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94e22af62d1684b19662c85b2d5011e3 |
| publicationDate |
2004-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1147181-B1 |
| titleOfInvention |
Replicative virus driven by the promoter for telomerase reverse transcriptase for use in treating cancer |
| abstract |
Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). Oncolytic viruses are described, in which a toxin or a genetic element essential for viral replication is placed under control of the TERT promoter. As a result, the virus replicates preferentially in cells expressing TERT, and selectively lyse cancer cells. The viral constructs of this invention hold considerable promise for the treatment of previously intractable malignancies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7378244-B2 |
| priorityDate |
1999-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |