| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7ddc4774cf5f8a0bda44a780d73c53d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 |
| filingDate |
2001-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3ef7b9c329a2e47bb4709db77f214d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c93789978adf317c3fa2b5e8422aeae2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_614222954ffd72f34492f7d7c7a84dff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff7cb3607e550602abf1f764b7480cbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4947d5ba7346635f106e982580504a67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_969bea33d84f47f37cc7fc17cc9da1df |
| publicationDate |
2001-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1134229-A2 |
| titleOfInvention |
Method of preparing clarithromycin of form II crystals |
| abstract |
High purity clarithromycin of Form II crystals can beneasily prepared in a high yield by a processncomprising the steps of: protecting the 9-oximenhydroxy group of erythromycin A 9-oxime or a saltnthereof with a tropyl group and the 2'- and 4''-hydroxyngroups with trimethylsilyl groups; reactingn2', 4" - O -bis (trimethylsilyl) erythromycin A 9- O -tropyloximenwith a methylating agent; removing thenprotecting groups and the oxime group of 2',4''- O -bis(trimethylsilyl)-6- O -methylerythromycinnA 9- O -tropyloximento obtain crude clarithromycin; treatingnthe crude clarithromycin with methanesulfonic acid inna mixture of a water-miscible organic solvent andnwater to obtain crystalline clarithromycin mesylatentrihydrate; and neutralizing the crystallinenclarithromycin mesylate trihydrate with aqueousnammonia in a mixture of a water-miscible organicnsolvent and water. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2221807-A1 |
| priorityDate |
2000-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |