abstract |
This invention relates to novel sequence and polymorphisms in the human flt-1 gene.nEight specific polymorphisms are identified. The invention also relates to methods andnmaterials for analysing allelic variation in the flt-1 gene and to the use of flt-1 polymorphismnin the diagnosis and treatment of angiogenic diseases and cancer. Diseases associated withnpathological angiogenesis include diabetic retinopathies, psoriasis, rheumatoid arthritis andnendometriosis. |