| abstract |
Oligonucleotides and other macromolecules are providednthat have increased nuclease resistance, substituentngroups for increasing binding affinity to complementarynstrand, and subsequences of 2'-deoxy- erythropentofuranosylnnucleotides that activate RNase H enzyme.nSuch oligonucleotides and macromolecules are useful forndiagnostics and other research purposes, for modulatingnprotein in organisms, and for the diagnosis, detectionnand treatment of other conditions susceptible tonantisense therapeutics. |