| abstract |
A (2-substituted oxyphenyl)alkanamide derivative or a salt thereof expressed by thenfollowing Formula (I):n nwherein one of A and B is a hydrocarbon group of C 3-30 expressed by R 1 and the other isn-(CH 2 )n-NR 2 R 3 ; Z is -CO- or -CONR 6 -; R 2 and R 3 individually represent H, lower alkyl ornbenzyl, or -NR 2 R 3 may be a heterocycle having 3-7 members; wherein -CONR 5 -(CH 2 )n-NR 2 R 3 nor -CONR 6 -(CH 2 )n-NR 2 R 3 may be the following Group (II):n nwherein ring Y is a heterocycle of 6 or 7 members; R 4 is selected from the group consisting ofnH, halogen, lower alkyl, lower acyl and etc; R 5 and R 6 are individually H, lower alkyl, lowernacyl or lower alkylcarbamoyl, or may form a part of said Group(II); l is 0 or 1; m is 1 or 2;nand n is an integer of 0-5. The (2-substituted oxyphenyl)alkanamide derivative or the saltnthereof has excellent hair growth and regrowth promoting effects, which are useful for care,nimprovement or prevention of hair loss in mammals and, in particular, in human. |