| abstract |
A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereofnexpressed by the following Formula (I):n nwherein one of A and B is a hydrocarbon group of C 10-30 expressed by R 1 and the other is -n(CH )n-NR 2 R 3 ; Z is -O-, -OCO-, -OCONR 6 - or -NR 6 -; R 2 and R 3 individually represent anhydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7nmembers; -NR 5 -(CH )n-NR 2 R 3 or -NR 6 -(CH )n-NR 2 R 3 may be Group W, and -OCONR 6 -(CH )n-NR 2 R 3 nmay be -OCO-W, wherein W is a formula of:n nwherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R 2 is anhydrogen, lower alkyl, phenyl or benzyl group; R 4 is a halogen, lower alkyl, lower acyl, nitro,ncyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lowernacylamino, lower alkoxy or lower acyloxy group; each of R 5 and R 6 is a hydrogen, lower alkyl,nlower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2;nand n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivativenor the salt thereof has excellent hair growth and regrowth promoting effects, which are usefulnfor care, improvement or prevention of hair loss in mammals and, in particular, in human. |