abstract |
Described is a substituted fused heterocyclic compound which is representednby the following formula:n n[wherein R 1 represents a group of the following formula:n n(in which R 4 : a substituted phenyl or a pyridyl which may have a substituent, R 5 : anhydrogen atom or the like, R 6 : a hydrogen atom, a C 1-6 alkyl group or the like, D: annoxygen or sulfur atom, E: a CH group or a nitrogen atom, R 2 : a hydrogen atom or thenlike, R 3 : a 2,4-dioxothiazolidin-5-ylmethyl group or the like; A: a C 1-6 alkylene group,nand B: an oxygen or sulfur atom] or a pharmacologically acceptable salt thereof; andnhas excellent insulin-resistance improving action, lipid-peroxide-production inhibitorynaction, 5-lipoxygenase inhibitory action and the like. |