| abstract |
The present invention relates to new compounds for the inhibition of blood clottingnproteins, and more particularly, to malonic acid derivatives of the formula I,n nwherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated in thenclaims. The compounds of formula I are inhibitors of the blood clotting enzyme factornXa. The invention also relates to processes for the preparation of the compounds ofnformula I, to methods of inhibiting factor Xa activity and of inhibiting blood clotting, tonthe use of the compounds of formula I in the treatment and prophylaxis of diseases,nwhich can be treated or prevented by the inhibition of factor Xa activity such asnthromboembolic diseases, and to the use of the compounds of formula I in thenpreparation of medicaments to be applied in such diseases. The invention furthernrelates to compositions containing a compound of formula I in admixture ornotherwise in association with an inert carrier, in particular pharmaceuticalncompositions containing a compound of formula I together with pharmaceuticallynacceptable carrier substances and auxiliary substances. |