| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f8cfa5aee4410611b5c562275c9f8e3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-72 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62 |
| filingDate |
1999-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4a3d36b911cc64a503760f3eeff9ce |
| publicationDate |
1999-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0939132-A1 |
| titleOfInvention |
Preparation of optically active alcohol substituted with one or more halogen atoms |
| abstract |
An optically active alcohol substituted with one or morenhalogen atoms, such as optically active 4-halo-3-hydroxybutyratenesters, is efficiently synthesized by using a secondary alcoholndehydrogenase and an alcohol as a substrate accompanied by thenrenaturing of NADH by asymmetrical reduction of a halogen-substitutednketone such as 4-haloacetoacetate esters at lowntemperature. By performing the reaction at low temperature, thentoxicity of a halogen-substituted ketone such as 4-haloacetoacetatenesters and of the optically active alcohol suchnas 4-halo-3-hydroxybutyrate esters, is diminished. In this way,nthe accumulated concentration of an optically active alcoholnsubstituted with one or more halogen atoms, such as 4-halo-3-hydroxybutyratenesters, may be increased while retaining the highnstereoselectivity of the secondary alcohol dehydrogenase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03035885-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0210422-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7157253-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017046319-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10152113-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3144393-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7135328-B2 |
| priorityDate |
1998-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |