| abstract |
The present invention is related to substituted pyrazolylnbenzenesulfonamides of the Formula In n wherein R 2 is selected from hydrido, C 1 -C 10 -alkyl, C 1 -C 6 -haloalkyl,nC 1 -C 6 -alkoxycarbonyl, cyano, carboxyl, C 1 -C 6 -cyanoalkyl,naminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 3 -C 7 -cycloalkylaminocarbonyl,narylaminocarbonyl, C 1 -C 6 -carboxyalkylaminocarbonyl, aryl-C 1 -C 6 -alkoxycarbonyl-C 1 -C 10 -alkylaminocarbonyl,nC 1 -C 6 -aminocarbonylalkyl, C 1 -C 6 -carboxyalkyl,nC 1 -C 6 -alkoxycarbonylcyano-C 2 -C 6 -alkenyl and C 1 -C 6 -hydroxyalkyl; n wherein R 3 is selected from hydrido, C 1 -C 10 -alkyl, cyano, C 1 -C 6 -hydroxyalkyl,nC 3 -C 7 -cycloalkyl, C 1 -C 6 -alkylsulfonyl, and halo; and n wherein R 4 is selected from optionally substituted C 3 -C 10 -cycloalkyl,nC 3 -C 10 - cycloalkenyl and heterocyclic; n provided R 2 and R 3 are not both hydrido, further provided that R 4 isnnot triazolyl when R 2 is methyl; and further provided that R 4 is notnsubstituted thienyl when R 2 is trifluoromethyl; or a pharmaceutically-acceptablensalt thereof. n The invention is also related to pharmaceutical compositions containingnsuch compounds. |