http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0784633-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e27e723c3f05c10ca760291231bacfb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-83 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 |
| filingDate | 1995-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62e90fd0e9ccbee84d11bcf0692e2b6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8adb34854e048a0b9dcfa60414e1b36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4b6d2fe8bd5e3bda96d72f1b1809386 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d655ec97d161a940d39d6f68c3dc96d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dd303a7be0cc0fb466b9d0cf3cdbcbb |
| publicationDate | 2005-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0784633-B1 |
| titleOfInvention | Process for purifying factor viii |
| abstract | PCT No. PCT/SE95/01351 Sec. 371 Date May 30, 1997 Sec. 102(e) Date May 30, 1997 PCT Filed Nov. 14, 1995 PCT Pub. No. WO96/15150 PCT Pub. Date May 23, 1996A process for reducing degradation of recombinant coagulation factor VIII caused by metal-dependent proteases requiring Zn2+ for activity or containing Zn2+ as an integral part of their structure comprises adding an inhibitor of Zn2+ dependent proteases to a recombinant factor VIII solution. The recombinant factor VIII solution is obtained after harvesting a conditioned medium from a cell culture used for producing the recombinant coagulation factor VIII. The inhibitor is selected from complexing agents with a stronger affinity for the Zn2+ ion of the protease than for the ion or ions stabilizing the factor VIII molecule, and compounds structurally related to the natural substrate of the protease and containing an electronegative moiety. |
| priorityDate | 1994-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 213.