| abstract |
Indoloylguanidine derivatives of formula (1) :n n wherein each R₁ is a substituent which may be hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, halogen, nitro, acyl, carboxyl, alkoxycarbonyl, an aromatic group, -OR₃, -NR₆R₇, -SO₂NR₆R₇ or -S(O) n R₄₀, and R₂ is hydrogen, alkyl, substituted alkyl, cycloalkyl, hydroxy, alkoxy or -CH₂R₂₀; and the pharmaceutically acceptable acid addition salts thereof; inhibit Na⁺/H⁺ exchanger activity and are consequently useful in the treatment or prevention of a disease caused by increased Na⁺/H⁺ exchanger activity. |