| abstract |
Benzoylguanidines of the formula I with R (1) or R (2) equal to R (6) -S (O) n - or R (7) R (8) N-O₂S- and the other substituent R (1) or R (2) is H, F, Cl, Br, J, alkyl, alkoxy or phenoxy, R (6) -S (O) n or R (7) R (8) N- and R (6) is alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R (7) and R (8) are alkyl or phenyl-alkyl- or phenyl, and wherein R (7) and R (8) may together be a C₄-C₇ chain, and wherein R (7) and R (8) together with the nitrogen atom to which they are attached are a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline System can mean and with R (3), R (4) and R (5) equal to hydrogen, alkyl or R (3) and R (4) together an alkylene chain or R (4) and R (5) together an alkylene chain, and with n equal to zero, 1 or 2 and their pharmaceutically acceptable salts are excellent antiarrhythmics.n n n You will get a procedure where one Compounds of formula II with a guanidine derivative of the formula III where X stands for an easily nucleophilically substitutable leaving group. |