| abstract |
A pyrimidine derivative represented by general formula (II) or (III) and a salt thereof, both having selective acetylcholine esterase inhibitor and type A monoamine oxidase inhibitor effects, thus being useful as antidepressant and senile dementia remedy. In said formulae, R¹ and R² represent each H, halogen, amino, nitro, (un)substituted alkyl, alkoxy or alkoxycarbonyl, provided that R¹ and R² may be combined together to represent (un)substituted alkylene; R³ represents aralkyl or heteroaryl-alkyl; R⁴ represents H or acyl; R⁵ represents H, OH or alkoxy; R⁶ represents H, halogen, alkyl or alkoxy; X represents -CH=, -CH=CH-(CH₂) p -, -CH₂- or -CH₂CH₂-(CH₂) p -; Y represents =CH-(CH₂) p -, -CH₂-(CH₂) p -, single bond or double bond; p represents 0 or 1; and symbol represents either single or double bond. |