| abstract |
A benzothiazolesulfonamide derivative represented by general formula (1) and having the activity of inhibiting protein phosphorylases such as protein kinase C and myosin light-chain kinase, a pharmaceutically acceptable acid-addition salt thereof, a process for producing the same, a medicinal composition containing the same, and a drug containing the same as the active ingredient for treating or preventing asthma on the basis of the protein phosphorylase inhibitor activity. In formula (1) A represents lower alkylene; R¹ represents hydrogen or lower alkyl; R² and R³ represent each independently hydrogen or lower alkyl, or they are combined together to represent lower alkylene; and R⁴ represents hydrogen, lower alkyl, amidino or phenyl-lower alkyl, wherein the phenyl group is mono- or disubstituted by lower alkyl, lower alkoxy, halogen or methylenedioxy. |