| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-867 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| filingDate |
1992-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c5ba359f8eb90657a3dbeb4b28123f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72188a490cfdfc9a645d68a3fd9d959f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2369e50dd42fffa4afaa4e3912e61f8a |
| publicationDate |
1993-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0531472-A1 |
| titleOfInvention |
Humanized and chimeric monoclonal antibodies |
| abstract |
The invention relates to novel humanized monoclonal antibodies comprising an artificial modified consensus sequence, at least for the FRs (framework regions) of the heavy chain variable region of a human immunoglobulin. The invention further relates to corresponding humanized and chimeric monoclonal antibodies which bind to epitopes of epidermal growth factor, where the responsible hypervariable regions have the following amino acid sequence: Light chain: CDR-1: -Ser -Ala-Ser-Ser-Ser-Val-Thr-Tyr-Met-Tyr-; CDR-2: -Asp-Thr-Ser-Asn-Leu-Ala-Ser-; CDR-3: -Gln-Gln-Trp-Ser-Ser-His-Ile-Phe-Thr- Heavy chain: CDR-1: -Ser-His-Trp-Met-His-; CDR-2: -Glu-Phe-Asn-Pro-Ser-Asn-Gly-Arg-Thr-Asn-Glu-Lys-Phe-Lys-Ser-; CDR-3: -Arg-Asp-Tyr-Asp-Tyr-Asp-Gly-Arg-Tyr-Phe-Asp-Tyr-. Antibodies can be used for therapeutic and diagnostic purposes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2251688-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10899816-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9522956-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1974723-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012175222-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020079209-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11485786-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11174320-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2004292742-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2004292742-B9
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3406723-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2537933-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2292251-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11306146-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2526967-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9555110-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014095088-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10358501-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10435472-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9725520-B2 |
| priorityDate |
1991-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |