abstract |
The invention concerns a benzodioxole derivative of the formula In n wherein Ar 1 is an optionally substituted 9- or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur ; R 1 is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl ; and R 2 and R 3 together form a group of the formula -A 1 -X-A 2 - which, together with the carbon atom to which A 1 and A 2 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A 1 and A 2 is (1-3C)alkylene and X is oxy, thio, sulphinyl or sulphonyl, and which ring may bear one or two substituents ; or a pharmaceutically-acceptable salt thereof ; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease. |