| abstract |
The invention concerns a bicyclic derivative of the formula I, or a pharmaceutically-acceptable salt thereof.n wherein Ar¹ is optionally substituted phenyl or naphthyl; nR¹ if (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and nR² and R³ together form a group of the formula -A¹-X-A²-, wherein each of A¹ and A² is (1-4C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino. n The invention also concerns processes for the manufacture of a bicyclic derivative of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said bicyclic derivatives. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase. |