| abstract |
Isoquinolinone derivatives of the formula:n n wherein R¹ is hydrogen, C1-4 alkyl, C1-4 alkoxy or a group of formula: n n -NR⁴R⁵ n nwherein R⁴ is hydrogen, halogen, C1-4 alkyl or C2-4 alkanoyl and nR⁵ is hydrogen, C1-4 alkyl or benzyl; nR² is hydrogen or C1-4 alkyl; nR³ is hydrogen or C1-4 alkyl; nl is 1, 2, 3 or 4; nm is 1 or 2; nn is 1 or 2 and n --- is a single bond or double bond and non-toxic acid addition salts thereof and hydrates thereof possess an antagonistic activity against 5-HT3 receptor, and are useful for the prevention and/or treatment of diseases induced when 5-HT acts on 5-HT3 receptors (especially vomiting induced by the administration of an anti-cancer agent). |