| abstract |
The invention provides imidazole derivatives of the general formula (I)n wherein Im represents an imidazolyl group of the formula:n and one of the groups represented by R³, R⁴ and R⁵ is a hydrogen atom, or a C₁₋₆alkyl, C₃₋₇cycloalkyl, C₃₋₆alkenyl, phenyl or phenylC₁₋₃alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C₁₋₆alkyl group; nR¹ and R² each represent a hydrogen atom, or together with the carbon atoms to which they are attached form a phenyl ring; nX represents an oxygen or a sulphur atom, or a group NR⁶, wherein R⁶ represents a C₁₋₆alkyl group; nZ-Y represents the group CH-CH₂ or C=CH; nand physiologically acceptable salts and solvates thereof. n The compounds of formula (I) are potent and selective antagonists of 5-hydroxytryptamine at 5-HT₃ receptors and are useful, for example, in the treatment of psychotic disorders, anxiety and nausea and vomiting. |