| abstract |
The invention relates to a salt of a basic histamine H₂-receptor antagonist of formula (I)n n and a complex of bismuth with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, or a solvate of such a salt, wherein n R¹ represents a group of formulan where R³ represents methyl or the group (CH₂)₂CONR⁴R⁵ in which R⁴ and R⁵ both represent ethyl groups; n R² represents a hydrogen atom or, when R¹ is the group -C(=CHNO₂)NHCH₃, R² may also represent a methyl group; and n n is 3 and X is oxygen, or n is 2 and X is CH₂ or sulphur; nwith the provisos that n(i) when R¹ representsn n then X is sulphur and n is 2; n(ii) when R¹ represents -C(=CHNO₂)NHCH₃ and R² is hydrogen, then X is oxygen and n is 3 or X is CH₂ and n is 2; and n(iii) when R¹ represents -C(=CHNO₂)NHCH₃ and R² is methyl, then X is oxygen and n is 3 or X is sulphur and n is 2. n The salts and solvates thereof are useful in the treatment of gastro-intestinal disorders, such as peptic ulcer disease, gastritis and non-ulcer dyspepsia. |