| abstract |
The invention relates to salts formed between basic H₂-receptor antagonists and a complex of bismuth with a carboxylic acid, and solvate of such salts, excluding salts in which the basic H₂-receptor antagonist is ranitidine. Examples of suitable carboxylic acids are citric acid and tartaric acid. Examples of basic H₂-receptor antagonists are cimetidine, sufotidine famotidine and nizatidine. n The salts ares useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity associated with the basic H₂-receptor antagonist together with antibacterial activity against Campylobacter pylori and they also possess cytoprotective properties. |