http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0375451-A3
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 |
| filingDate | 1989-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1991-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0375451-A3 |
| titleOfInvention | Compounds having a renin-inhibiting activity |
| abstract | Compounds of formula (I) and pharmaceutically nacceptable salts thereof: n nwherein nZ₁, Z₂, Z₃ and the carbon atoms to which Z₁ and Z₃ are nattached, form a 5-membered non-aromatic nheterocyclic ring; nE is absent or is (CH₂) n or CH(CH₂) n-1 wherein n is 1 nto 4; nA is -CONH-, -NHCO-, -COO- -S(O) r - wherein r is 0, 1, nor 2, or -CH₂-; np is 0, 1 or 2; nq is 0 or 1; ns is 0, 1, 2, 3 or 4; nR z is hydrogen, C₁₋₆ alkyl or, when A is -CH₂-, nhydroxy; nR a and R b are independently selected from hydrogen or a nsubstituent; nR₁ is CH₂R₉ wherein R₉ is optionally substituted aryl nor heteroaryl; nR₂ is CHR₁₀R₁₁ wherein R₁₀ is hydrogen or methyl and nR₁₁ is C₁₋₆ alkyl, C₃₋₈ cycloalkyl, optionally nsubstituted aryl or heteroaryl, or R₁₁ is amino, nC₂₋₇ alkanoylamino, 2-oxopyrrolidinyl, n2-oxopiperidinyl or C₁₋₆ alkoxycarbonylamino; n n nR₃ is CH₂R₁₂ wherein R₁₂ is C₁₋₆ alkyl, C₃₋₈ ncycloalkyl or phenyl; and nR₄ is a saturated or unsaturated heterocyclic ring nlinked through carbon, hydroxy, C₁₋₆ alkoxy, nC₁₋₇ alkanoyloxy, amino, C₁₋₇ alkanoylamino, namino substituted by one or two C₁₋₆ alkyl ngroups, C₁₋₆ alkylsulphonyl, carboxy, C₁₋₆ nalkoxycarbonyl, benzyloxycarbonyl, aminocarbonyl nor CH(NHR₁₃)CO₂R₁₄ wherein R₁₃ is hydrogen or nC₁₋₆ alkanoyl and R₁₄ is hydrogen or C₁₋₆ alkyl; nor (when s is 2 to 4) R₄ is a saturated or nunsaturated heterocyclic ring linked through nnitrogen; and nthe dashed line represents an optional bond (when E is npresent); nwhich are renin inhibitors, a process for their npreparation and their use as pharmaceuticals. |
| priorityDate | 1988-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.