http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0362031-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24192536a4ce2f93d3ccf79d03771802 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1989-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db7f60d4d6d5ab1fc93df41074bfff7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f0544ab5a29dfb2134b54e41c7f97b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53d4b2a10fbc049e0925b408d0a6f7a9 |
| publicationDate | 1990-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0362031-A1 |
| titleOfInvention | Compounds active against malaria of the tissues, and process for their preparation |
| abstract | The invention relates to novel quinoline derivatives containing a free amine function and having antimalarial properties, in particular new derivatives of primaquine or their addition salts with acids, and their preparation process.n n n According to the invention, these new derivatives are represented schematically by the formula: PQ - X in which PQ represents quinolines containing a free amine function and having antimalarial properties, in particular primaquine; X represents an amino acid or a peptide of 2 to 4 amino acids; and the PQ-X bond being a covalent peptide bond between the free amine group of PQ and the carboxylic group of X, the covalent bond PQ-X being stable in serum and resistant to lysosomal hydrolases.n n n In one embodiment of the invention, the amino acid or the first amino acid of peptide linked to PQ is gamma L-glutamic acid or beta aspartic acid linked to PQ by their gamma- or beta-carboxyl group, or L-pyroglutamic acid or aspartic acid linked to PQ by their alpha-carboxyl group. |
| priorityDate | 1988-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.