| abstract |
Compounds of formula (I)n in which X¹, X² and X³ are hydrogen, halogen, CF₃, C₁₋₆alkyl, OH, C₁₋₆alkoxy, CN, NO₂, N(R¹)₂, CHO or CO₂R¹; A is O or S, n is 0 or 1, R¹ is H or C₁₋₈alkyl and R³ is α-H, α-OH, or α-acetoxy and β=WCOR⁴, β-alkOR⁸; or =CHWCOR⁴ or =CHWOR⁸; furanyl or α-H and β-NHCOR⁹, β-cyano or β-tetrazolyl; or keto; processes for their preparation, intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of steroid 5-α-reductase activity. |