| abstract |
Compounds of structure (I):n in which R¹ is hydrogen, C₁₋₆alkyl, C₁₋₆alkoxy, C₁₋₆alkoxy-C₁₋₆-alkyl, C₃₋₆cycloalkyl, C₃₋₆cycloalkylC₁₋₆alkyl, phenyl, phenylC₁₋₆alkyl, the phenyl groups being optionally substituted; R² is hydrogen, C₁₋₆alkyl, C₁₋₆alkoxy, amino C₁₋₆alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C₁₋₆alkanoyl or trifluoromethyl; m is 1 to 3; p is 0 to 4; R³ is COR⁴; R⁴ is hydroxy, C₁₋₆alkoxy or NR⁵R⁶; R⁵ and R⁶ are each hydrogen or C₁₋₆alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; and R⁷ is hydrogen, hydroxy, C₁₋₆alkoxy or C₁₋₆alkyl, processes for preparing them, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors for gastric acid secretions. |