| abstract |
Phenoxyethylamine derivatives represented by the general formula (I):n wherein R₁ and R₅ represent lower-alkyl, R₂ and R₃, which may be the same or different, each represents hydrogen or lower-alkyl, orn represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R₄ represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent α₁-blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed. |