| abstract |
Therapeutically useful isoquinolinone derivatives of the formula A-X-R³, wherein A represents a group of the formula:n wherein R¹ and R² represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R⁴ represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R⁶O- wherein R⁶ represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R³ represents a group of the formula:- n-Y¹-CH₂-CH(OH)-CH₂-COOR⁵ nwherein Y¹ represents carbonyl, hydroxymethylene or -C(OR)₂- wherein R represents alkyl or the two R symbols together represent alkylene and R⁵ represents hydrogen or optionally substituted alkyl or R³ represents a lactol or lactone ring, and pharmaceutically acceptable salts thereof, processes for their preparation and compositions containing them are described. |