| abstract |
Lipid derivatives represented by the formula:n EMI ID=2 98/1 HE= 30 WI= 7 5 TI=CHE nwherein R 1 is alkyl or alkylcarbamoyl; R 2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or heterocyclyloxy; R 2 ' is hydrogen or R 2 and R 2 ' taken together form -O(CH 2 ) m -wherein m is an integer of 1 to 5; Rs, R 4 , and Rs each is hydrogen or lower alkyl or two or three of R 3 , R 4 , and R 5 taken together with the adjacent nitrogen atom form cyclic ammonio; R 5 is hydrogen or lower alkylcarbonyl; X- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconsticting agent or antitumor agent. |