| abstract |
Novel pyridazinamine derivatives of formulan wherein nR¹ is hydrogen, C₁₋₆alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C₁₋₆alkyl)amino, cyano, C₁₋₆alkyloxy, aryloxy, arylC₁₋₆alkyloxy, C₁₋₆alkylthio, arylthio, C₁₋₆alkylsulfinyl, C₁₋₆alkylsulfonyl, arylsulfinyl, aryllsulfonyl, C₁₋₆alkyloxycarbonyl, C₁₋₆alkylcarbonyl or aryl; nR² and R³ each independently are hydrogen or C₁₋₆alkyl, or R² and R³ combined may form a bivalent radical of formula -CH=CH-CH=CH- nG is a bivalent radical of formulan X is O, S, NR⁸ or a direct bond; said R⁸ being hydrogen or C₋₆alkyl; nthe pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-virals; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions. |